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Advanced Biomaterials and Devices in Medicine
June 2018, Volume 5, Issue 1, pp 1–6
Histological evaluation of tissue damage caused by bioinspired needle insertion
M. Sahlabadi1, S.T.R. Gidde1, P. Gehret2, K. Esmaeili Pourfarhangi2, B. Bayarmagnai2, P. Hutapea1*
1 Department of Mechanical Engineering, Temple University, Philadelphia, PA 19122 USA
2 Department of Bioengineering, Temple University, Philadelphia, PA 19122 USA
* Corresponding author: Assoc. Prof. Parsaoran Hutapea, e-mail: hutapea@temple.edu
Abstract
A novel bioinspired design for surgical needles was proposed in our previous work which reduces insertion and extraction forces during needle-based procedures. The results obtained from insertion and extraction tests into artificial and biological tissues showed 35–45% reduction in the insertion force, and 15–20% reduction in the extraction force using bioinspired needles. From literature, it has been known that reducing needle forces results in less invasive medical procedure. In this paper, a histological study was conducted to accurately measure the tissue damage caused by needles to tissue. The insertion tests into bovine liver tissue were performed using bioinspired and conventional needles. Liver tissue samples were fixed and sectioned into slices with the thickness of 0.08 μm and stained using hematoxylin and eosin staining method to enhance visualization of the cells. The results obtained from the histological study showed that the tissue damage was decreased by 31% using bioinspired needle. The results obtained from the histological study strongly supports our previous assumption that reducing needle’s forces and the tissue deformation during an insertion results in less tissue damage. Therefore, the proposed bioinspired design can be implemented to design surgical needles which are more accurate and less invasive.
Keywords: histological study, tissue damage, bioinspired design, honeybee, medical devices, insertion force
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